Endocrine Abstracts

Inability to store excess lipids in the subcutaneous adipose tissue leads to ectopic lipid deposition in several sites including the liver, skeletal muscles, intra-abdominal and pericardial depots. This, in turn, has negative consequences for degree of insulin sensitivity and the dysmetabolic state associated with insulin resistance and type 2 diabetes.Storage of fat in the adipose tissue can either lead to inappropriate cellular enlargement (hypertrophi...